If EVE crashes the instant that you load ISXEVE or if ISXEVE is working fine one day, and then not working the next day - and there was an EVE patch in-between these instances , then you need to do the following:
Wait for a new release of ISXEVE (isxeve.dll) that is time-stamped later than your current ExeFile.exe. If you're impatient, come on IRC and help test.
You can play EVE with the debugger attached forever without harming your playing experience.
You'll want to make sure you're playing in the windowed mode, not full screen mode -- otherwise you won't be able to get to WinDbg when the crash occurs.
Run WinDbg Before or after EVE loads, doesn't matter
Hit 'F6' and select "exefile.exe" from the list. This can be done at any time, as long as EVE hasn't crashed yet
Execute the following commands in WinDbg:
!load wow64exts (It's ok if this fails, it's only in case you're running the x64 debugger)
.effmach x86 (It's ok if this fails, it's only in case you're running the x64 debugger)
Extended instructions are required for .NET applications
Extended instructions result in a superset of Basic instruction logs, so if you want to run them anyway, feel free.